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O-59 - Computational analysis predicts the SARS-CoV-2 RBD-ACE2 interaction is not ideal - non-optimal

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type
observation
id
O-59
statement
Computational structural analyses predict that the SARS-CoV-2 RBD-human-ACE2 interaction is 'not ideal' and that its RBD sequence differs from the residues shown in SARS-CoV to be optimal for receptor binding, despite the virus binding hACE2 with high affinity in practice.
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S-46 - Andersen et al. 2020 — The Proximal Origin of SARS-CoV-2
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Section 'Notable features'
quote
computational analyses predict that the interaction is not ideal and that the RBD sequence is different from those shown in SARS-CoV to be optimal for receptor binding
data_basis

Computational structural analyses predict that the SARS-CoV-2 RBD-human-ACE2 interaction is ‘not ideal’ and that its RBD sequence differs from the residues shown in SARS-CoV to be optimal for receptor binding, despite the virus binding hACE2 with high affinity in practice.

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