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O-60 - Polybasic furin cleavage site (PRRA insertion) at the S1-S2 junction, absent in related lineage B betacoronaviruses

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Properties8
type
observation
id
O-60
statement
SARS-CoV-2 has a polybasic (furin) cleavage site formed by a 12-nucleotide insertion adding the amino acids PRRA (yielding an RRAR motif) at the S1/S2 boundary of the spike; such sites are absent in the related lineage B betacoronaviruses.
link_state
linked
source
S-46 - Andersen et al. 2020 — The Proximal Origin of SARS-CoV-2
locator
Section 'Notable features'
quote
Polybasic cleavage sites have not been observed in related 'lineage B' betacoronaviruses
data_basis

SARS-CoV-2 has a polybasic (furin) cleavage site formed by a 12-nucleotide insertion adding the amino acids PRRA (yielding an RRAR motif) at the S1/S2 boundary of the spike; such sites are absent in the related lineage B betacoronaviruses.

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