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O-67 - All BsaI-BsmBI-site differences from RaTG13-BANAL-52 are silent, at an elevated rate

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Properties7
type
observation
id
O-67
statement
All 12 nucleotide differences at BsaI/BsmBI sites between RaTG13 and SARS-CoV-2, and all 5 between BANAL-52 and SARS-CoV-2, are synonymous (silent); the rate of silent mutations within these recognition sites is significantly higher than across the rest of the genome (RaTG13 OR=8.9, P=9e-8; BANAL-52 OR=5.2, P=0.004).
link_state
linked
source
S-48 - Bruttel, Washburne & VanDongen 2022-23 — Endonuclease fingerprint indicates a synthetic origin
locator
Results (silent-mutation analysis)
data_basis

All 12 nucleotide differences at BsaI/BsmBI sites between RaTG13 and SARS-CoV-2, and all 5 between BANAL-52 and SARS-CoV-2, are synonymous (silent); the rate of silent mutations within these recognition sites is significantly higher than across the rest of the genome (RaTG13 OR=8.9, P=9e-8; BANAL-52 OR=5.2, P=0.004).

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