EpiStack

O-74 - SARS-CoV-2 has a RaTG13-like backbone but a pangolin-CoV-like RBD (chimeric structure)

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Properties8
type
observation
id
O-74
statement
SARS-CoV-2 is ~96.2% identical genome-wide to bat CoV RaTG13 (its closest full-genome relative) and 79% to SARS-CoV, yet its RBD is nearly identical to the pangolin coronavirus MP789: SARS-CoV-2 and pangolin CoV share identical amino acids at the five critical RBD contact residues while RaTG13 shares only one - a chimeric backbone-vs-RBD split.
link_state
linked
source
S-54 - Segreto Deigin 2021 — The genetic structure of SARS-CoV-2 does not rule out a laboratory origin
locator
Sections 'SARS-CoV-2's closest relatives...' and 'SARS-CoV-2 shares its RBD with a pangolin CoV'
quote
pangolin CoVs and SARS-CoV-2 possess identical amino acids at the five critical residues of the RBD, whereas RaTG13 only shares one amino acid with SARS-CoV-2
data_basis

SARS-CoV-2 is ~96.2% identical genome-wide to bat CoV RaTG13 (its closest full-genome relative) and 79% to SARS-CoV, yet its RBD is nearly identical to the pangolin coronavirus MP789: SARS-CoV-2 and pangolin CoV share identical amino acids at the five critical RBD contact residues while RaTG13 shares only one - a chimeric backbone-vs-RBD split.

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