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O-75 - The furin site is a 12-nt PRRA insert with a rare doubled CGG-CGG arginine codon and a FauI site

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Properties8
type
observation
id
O-75
statement
The SARS-CoV-2 furin cleavage site is created by a 12-nucleotide insert (TCCTCGGCGGGC) coding PRRA at the S1/S2 junction; the two adjacent arginines are encoded by CGG-CGG, a rare codon in these viruses (only ~5% of arginines use CGG, and this is the only doubled CGG in the genome), and the insert contains a FauI restriction site.
link_state
linked
source
S-54 - Segreto Deigin 2021 — The genetic structure of SARS-CoV-2 does not rule out a laboratory origin
locator
Section 'The furin cleavage site...'; Fig 1
quote
the two joint arginines are coded by two CGGCGG codons, which are rare for these viruses: only 5% of arginines are coded by CGG in SARS-CoV-2 or RaTG13, and CGGCGG in the new insert is the only doubled instance of this codon in SARS-CoV-2
data_basis

The SARS-CoV-2 furin cleavage site is created by a 12-nucleotide insert (TCCTCGGCGGGC) coding PRRA at the S1/S2 junction; the two adjacent arginines are encoded by CGG-CGG, a rare codon in these viruses (only ~5% of arginines use CGG, and this is the only doubled CGG in the genome), and the insert contains a FauI restriction site.

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