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EpiStack v1 — FLF competition
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analyses
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eggs
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arguments
Folder: v1/analyses/eggs/arguments
42 items under this folder.
Jul 23, 2026
A-1 - Rise coinciding with failed synthesis suppression against a compensating majority implies a feedback-control responder mechanism
Jul 23, 2026
A-10 - US-only egg-T2D signal plus null after cholesterol-protein adjustment supports eggs marking a dietary pattern rather than causing T2D
Jul 23, 2026
A-11 - Germ-free-antibiotic necessity plus TMAO-supplementation sufficiency plus host-genetic segregation jointly establish a causal choline--flora--TMAO--atherosclerosis chain in mice
Jul 23, 2026
A-12 - Human TMAO-CVD evidence is observational in a selected angiography cohort, so it supports but does not establish human causality
Jul 23, 2026
A-13 - Isocaloric substitution algebra makes the egg effect the difference of two food coefficients, so no unconditional egg effect is identified
Jul 23, 2026
A-14 - Full-serving-per-day substitution benefits apply only to the small high-intake minority, so population impact of cutting eggs is smaller
Jul 23, 2026
A-15 - Observed egg LDL-C change was far below the dietary-cholesterol dose-response prediction, consistent with yolk phospholipids blunting absorption
Jul 23, 2026
A-16 - Crude-to-adjusted reversal shows the egg-CVD association is confounded by an unhealthy-eater pattern
Jul 23, 2026
A-17 - E-value- confounding of RR-=1.43 would be needed to turn the egg-CVD null positive
Jul 23, 2026
A-18 - Region-structured heterogeneity favors population effect-modification over a universal egg-CVD null
Jul 23, 2026
A-19 - Self-reported T2D over a short 5-year follow-up biases toward the null, so the JPHC egg null under-discriminates
Jul 23, 2026
A-2 - A registered RCT null in the exact at-risk population causally counterweights the cohort harm signal (with a background-diet-match caveat)
Jul 23, 2026
A-20 - The closed-form E-value formula shows small cohort hazard ratios need only modest unmeasured confounding to be explained away
Jul 23, 2026
A-21 - Egg association vanishing on cholesterol adjustment implies dietary cholesterol is the operative exposure
Jul 23, 2026
A-22 - Choline was absorbed in the egg arm yet TMAO did not rise, isolating choline form (not dose or compliance) as the TMAO determinant
Jul 23, 2026
A-23 - Because TMAO is cleared almost exclusively by the kidney, the normal-renal egg-null cannot be extrapolated to renal impairment
Jul 23, 2026
A-24 - Adverse egg-CVD HR confined to the diabetic stratum supports effect-modification by diabetes, but the small subgroup makes it imprecise
Jul 23, 2026
A-25 - Implausible, mutually incompatible implied effects mark the cohort estimates as bias-driven not causal
Jul 23, 2026
A-26 - Universal correlation among dietary variables plus unmeasured behavioral confounding and flexible analysis make single-food effects non-identifiable in cohorts
Jul 23, 2026
A-27 - The parallel ~10% apoB rise means added egg cholesterol raises atherogenic LDL-particle number, not just cholesterol per particle
Jul 23, 2026
A-28 - Small, CI-crossing genotype effects for fat and cafestol and none for dietary cholesterol imply APOE genotyping has little practical value for identifying diet-responders
Jul 23, 2026
A-29 - FFQ under-reporting is large and BMI-correlated, violating the classical measurement-error model that standard attenuation correction assumes
Jul 23, 2026
A-3 - Haemorrhagic-stroke-driven benefit limits transfer of China Kadoorie protective signal to Western populations
Jul 23, 2026
A-30 - High event count makes PURE's tight null informative against a moderate harm or benefit of eggs
Jul 23, 2026
A-31 - Absence of any adverse lipid change removes the main a-priori pathway for egg harm, making the null mechanistically coherent
Jul 23, 2026
A-32 - Isolated MI and prevalent-CVD-subgroup signals are best read as chance given multiplicity and non-replication
Jul 23, 2026
A-33 - Reversible depletion plus liver dysfunction on choline removal from an otherwise-complete diet meets the criterion for essentiality
Jul 23, 2026
A-34 - HDL rose while LDL and the LDL-HDL ratio held across absorber phenotypes, so the egg lipid effect is neutral-to-favorable rather than atherogenic
Jul 23, 2026
A-35 - Non-differential, calibratable dietary error biases against not toward positive findings, so measurement error is correctable rather than fatal
Jul 23, 2026
A-36 - Replication across cohorts with different confounding structures plus sensitivity analysis makes residual confounding an unlikely and bounded explanation
Jul 23, 2026
A-37 - Triangulating cohorts with mechanism and intermediate-endpoint trials supports causal inference for policy given hard-endpoint diet RCTs are often infeasible
Jul 23, 2026
A-38 - Reverse causation from subclinical disease is removable by prospective design plus early-follow-up exclusion and lag analyses
Jul 23, 2026
A-39 - The -=2-yolk threshold and 4-6 yolk plateau imply saturating conversion capacity, bounding TMAO exposure from high egg intake
Jul 23, 2026
A-4 - Identical eczema treatment in both arms isolates the causal effect of egg introduction, not eczema management
Jul 23, 2026
A-40 - A postprandial TMAO spike with unchanged inflammation-oxidation markers does not establish that egg-driven TMAO causes harm
Jul 23, 2026
A-41 - Elevated risk at both intake extremes within one cohort refutes any monotone egg-CVD dose-response for this population
Jul 23, 2026
A-42 - The low-intake arm of the U may overstate harm because very low egg intake marks low socioeconomic status and poor health
Jul 23, 2026
A-5 - Region- and diet-quality-dependence plus incomplete attenuation point to the US egg-T2D signal being confounded by the Western dietary pattern
Jul 23, 2026
A-6 - Substitution pattern - eggs worse than plant foods and dairy but equivalent to other animal proteins - fits eggs as an animal-food marker rather than a unique cause
Jul 23, 2026
A-7 - Illness from intact refrigerated Grade A eggs excludes shell contamination and implies internal trans-ovarian origin
Jul 23, 2026
A-8 - Serotype-specific egg association (SE 44% vs 15% others) points to eggs as the SE-specific vehicle
Jul 23, 2026
A-9 - Keys square-root dose-response equation makes the dietary-cholesterol effect concave (diminishing returns)
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