EpiStack

O-11 - 2018 EcoHealth-WIV DEFUSE proposal sought to insert furin cleavage sites into SARS-related bat coronavirus spikes

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Properties7
type
observation
id
O-11
statement
The 2018 DEFUSE proposal (~$14.2M, EcoHealth Alliance to DARPA PREEMPT, with WIV, Duke-NUS, UNC and others) proposed synthesizing full-length infectious clones of SARS-related bat coronaviruses and inserting novel/human-adapted proteolytic (furin) cleavage sites into their spikes, then testing growth/infectivity in humanized mice and human airway cultures.
source
S-15 - DEFUSE proposal 2018 - leaked EcoHealth Alliance-WIV DARPA grant application proposing furin cleavage site insertion into bat coronaviruses
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Proposal body; aims/tasks (spike modification)
data_basis
link_state
linked

Reading of the leaked funding-proposal artifact. Establishes documented intent and stated capability to perform this specific class of spike modification at the implicated institutions. It is a proposed experiment, not evidence it was performed.

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