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O-9 - BANAL-236 RBD binds human ACE2 like SARS-CoV-2 and the virus replicates in human cells in vitro

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type
observation
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O-9
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BANAL-236's receptor-binding domain binds human ACE2 with affinity similar to SARS-CoV-2's, and the virus replicates in human cells in vitro.
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S-12 - Temmam 2022 Nature - BANAL bat coronaviruses from Laos are SARS-CoV-2's closest known relatives and infect human cells
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Results; ACE2-binding and cell-infection assays
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linked

Wet-lab binding + infectivity assays on a wild-caught bat virus. Demonstrates a naturally occurring, human-cell-infectious SARS-CoV-2-like RBD.

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