summary - Pooled analysis of 146,011 people across 21 countries in the PURE study plus 31,544 vascular-disease patients in the ONTARGET/TRANSCEND trials (50 countries total, 6 continents; 14,700 composite events in PURE). Found no significant association between egg intake and blood lipids, all-cause mortality, or major CVD events in the primary analyses; a higher-intake/lower-MI signal appeared in PURE alone but was not replicated in the other two studies, so the authors flag it as likely spurious.
relevance_note - The most geographically diverse hard-endpoint cohort evidence (low/middle/high-income countries), and a clean null result contrasting with the US-only harm findings.