summary - Harvard group’s own cohort analysis (NHS 1980-2012, NHS II 1991-2013, HPFS 1986-2012; combined n=215,618, >5.5M person-years, 14,806 incident CVD cases) plus an updated meta-analysis of prospective cohort studies (~1.72M participants). In the pooled Harvard cohorts, at least 1 egg/day was not associated with incident CVD risk after adjusting for updated lifestyle/dietary confounders (HR 0.93 vs <1/month, CI crossing 1); the meta-analysis likewise found no appreciable association between moderate egg intake and CVD, CHD, or stroke. Its meta-analysis section is a discovery hub for other cohort references, not itself a separate primary.
relevance_note - The largest/most current null result from the historically most-studied US cohort family; direct counterweight to Zhong 2019’s harm finding.