Summary: Prospective cohort analysis restricted to 5,672 women with type 2 diabetes within the Nurses’ Health Study, followed 1980–1998 (619 incident CVD cases: nonfatal MI, fatal CHD, stroke). Higher dietary cholesterol intake was associated with higher CVD risk (RR 1.37 per 200 mg cholesterol/1000 kcal, 95% CI 1.12–1.68); higher saturated fat also raised risk, and replacing 5% of energy from saturated fat with monounsaturated fat was associated with 37% lower risk. Outcome is a hard clinical endpoint (CVD events), not a surrogate marker.
Relevance: A dedicated diabetic-cohort analysis (restricted to T2D women from the start, not a subgroup carve-out of a general-population paper) finding a dietary-cholesterol-linked CVD risk gradient specifically in T2D — the key anti-egg heterogeneity anchor with a hard endpoint, counterbalancing DIABEGG/Ballesteros.