Summary: Prospective analysis of 20,703 men (Physicians’ Health Study I, 1982–2007) and 36,295 women (Women’s Health Study, 1992–2007) free of diabetes, CVD, and cancer at baseline. Egg intake was categorized (none, <1/week, 1/week–<1/day, ≥1/day); over mean follow-up of 20.0 (men) and 11.7 (women) years, 1,921 men and 2,112 women developed type 2 diabetes. ≥1 egg/day was associated with 58% higher T2D risk in men and 77% higher in women vs. no eggs, with a graded increase across intake categories. Outcome is a hard endpoint (incident T2D).
Relevance: The clearest dose-response primary in this slice: models the shape of risk above and below ~1 egg/day for a diabetes-incidence hard endpoint, and finds a graded (not obviously threshold-only) anti-egg gradient — direct evidence on “at what level.”