summary - Individual-participant pooled analysis of 6 US prospective cohorts (ARIC, CARDIA, Framingham Heart/Offspring, Jackson Heart, MESA; n=29,615, 31.1% Black, followed up to 31 years) run through the NHLBI Lifetime Risk Pooling Project. Each additional 300 mg/day of dietary cholesterol was associated with 17% higher incident CVD and 18% higher all-cause mortality (adjusted HR); each additional half-egg/day was associated with 6% higher CVD and 8% higher mortality, in a roughly monotonic dose-response pattern that persisted (somewhat attenuated) after adjusting for other diet/lifestyle factors.
relevance_note - The headline harm-finding hard-endpoint cohort result; large, diverse, long follow-up, and the most-cited source anchoring the anti-egg side of the hard-endpoint debate.