O-64 - Malayan pangolin coronaviruses share all six key RBD residues with SARS-CoV-2
Coronaviruses from Malayan pangolins show strong RBD similarity to SARS-CoV-2, including identity at all six key ACE2-contact RBD residues.
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Why this is evidence
A natural pangolin coronavirus carrying all six key ACE2-contact RBD residues supplies a natural donor for the human-binding interface — favouring H-41/H-42 (natural recombination) over an engineered RBD (H-43).