O-36 - DEFUSE proposed inserting field-sampled bat spike proteins into WIV1-SHC014 backbones and infecting humanized (hACE2) mice to assess SARS-like disease capacity
The core proposed gain-of-function-style activity: constructing chimeric bat coronaviruses and testing their human-disease potential in hACE2 mice. (Quote reconciled from degraded OCR of the scanned proposal.)
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Why this is evidence
A written plan to build chimeric bat coronaviruses (field spikes into WIV1/SHC014 backbones) and test them in hACE2 mice documents gain-of-function-style engineering capability and intent at the consortium — favouring H-43, and research proximity over H-41.