EpiStack

H-32 - SARS-CoV-2's human-adapted features arose by natural selection in an animal host before zoonotic transfer

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Properties8
type
hypothesis
id
H-32
state
merged
question
Where did SARS-CoV-2 acquire its human-adapted RBD and furin cleavage site - in an animal host before spillover, in humans after spillover, or in cell culture?
statement
The optimized RBD and the polybasic furin cleavage site were acquired through natural selection in an animal reservoir (e.g. bats/pangolins) prior to the virus jumping to humans.
merged_into
H-41 - Natural zoonotic spillover with no research involvement
source
S-46 - Andersen et al. 2020 — The Proximal Origin of SARS-CoV-2
locator
Discussion (scenario i)

The optimized RBD and the polybasic furin cleavage site were acquired through natural selection in an animal reservoir (e.g. bats/pangolins) prior to the virus jumping to humans.

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