EpiStack

H-33 - Some SARS-CoV-2 features arose by natural selection during cryptic human-to-human transmission after an early spillover

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Properties8
type
hypothesis
id
H-33
state
merged
question
Where did SARS-CoV-2 acquire its human-adapted RBD and furin cleavage site - in an animal host before spillover, in humans after spillover, or in cell culture?
statement
A progenitor jumped to humans carrying an already-optimized RBD and subsequently acquired the polybasic furin cleavage site (and other adaptations) during undetected human-to-human transmission.
merged_into
H-41 - Natural zoonotic spillover with no research involvement
source
S-46 - Andersen et al. 2020 — The Proximal Origin of SARS-CoV-2
locator
Discussion (scenario ii)

A progenitor jumped to humans carrying an already-optimized RBD and subsequently acquired the polybasic furin cleavage site (and other adaptations) during undetected human-to-human transmission.

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