EpiStack

H-37 - SARS-CoV-2's human-ACE2-binding RBD and backbone arose by natural recombination among wild bat viruses

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Properties8
type
hypothesis
id
H-37
state
merged
question
Did SARS-CoV-2's human-ACE2-adapted RBD and backbone arise naturally in wild bats or require lab engineering/adaptation?
statement
SARS-CoV-2's genome apart from the furin cleavage site - including its human-ACE2-optimized RBD - is explained by natural recombination among wild bat sarbecoviruses of this Indochinese pool, requiring no laboratory engineering or adaptation of the RBD.
merged_into
H-41 - Natural zoonotic spillover with no research involvement
source
S-52 - Temmam et al. 2022 Nature — BANAL Laos bat coronaviruses
locator
Discussion

SARS-CoV-2’s genome apart from the furin cleavage site - including its human-ACE2-optimized RBD - is explained by natural recombination among wild bat sarbecoviruses of this Indochinese pool, requiring no laboratory engineering or adaptation of the RBD.

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added after the FLF submission deadline

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