EpiStack

H-38 - SARS-CoV-2's furin cleavage site was acquired separately, by a route not represented in the closest bat relatives

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Properties8
type
hypothesis
id
H-38
state
merged
question
When and by what route did SARS-CoV-2 acquire its furin cleavage site, given its absence in the closest bat relatives?
statement
Because the closest wild relatives all lack a furin cleavage site, SARS-CoV-2 acquired its FCS by a distinct later event whose route (natural or otherwise) is not accounted for by these bat genomes.
merged_into
H-41 - Natural zoonotic spillover with no research involvement
source
S-52 - Temmam et al. 2022 Nature — BANAL Laos bat coronaviruses
locator
Discussion

Because the closest wild relatives all lack a furin cleavage site, SARS-CoV-2 acquired its FCS by a distinct later event whose route (natural or otherwise) is not accounted for by these bat genomes.

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