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H-39 - SARS-CoV-2 is a laboratory-engineered chimera (RaTG13-like backbone + pangolin-like RBD + site-directed furin site)

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Properties9
type
hypothesis
id
H-39
state
merged
question
Was SARS-CoV-2 assembled/engineered in a laboratory (chimera construction plus site-directed mutagenesis) rather than arising naturally?
statement
SARS-CoV-2 was created in the lab by combining a RaTG13-like bat backbone with a pangolin-CoV-like RBD and inserting the furin cleavage site by site-directed mutagenesis, producing a chimera that would appear natural.
merged_into
H-43 - Research-related origin of a laboratory-manipulated virus (engineered lab leak)
source
S-54 - Segreto Deigin 2021 — The genetic structure of SARS-CoV-2 does not rule out a laboratory origin
locator
Abstract / Discussion
quote
By combining a bat coronavirus backbone and a receptor binding domain from pangolin coronavirus the resulting chimera would seem completely natural

SARS-CoV-2 was created in the lab by combining a RaTG13-like bat backbone with a pangolin-CoV-like RBD and inserting the furin cleavage site by site-directed mutagenesis, producing a chimera that would appear natural.

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