The optimal adaptation of SARS-CoV-2’s RBD to human ACE2 (and possibly the O-linked glycans) could have been achieved by serial passage of a chimeric or bat virus in cell culture or in humanized/hACE2-expressing animals in the lab.
The optimal adaptation of SARS-CoV-2’s RBD to human ACE2 (and possibly the O-linked glycans) could have been achieved by serial passage of a chimeric or bat virus in cell culture or in humanized/hACE2-expressing animals in the lab.