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H-6 - The A-B intermediate haplotypes did not genuinely circulate in humans

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Properties9
type
hypothesis
id
H-6
state
merged
question
Did a genuine intermediate genotype linking lineages A and B circulate in humans, as expected if a single introduction diversified within humans?
statement
No genuine intermediate genotype (C/C or T/T) connecting lineages A and B circulated in humans; the apparent intermediate genomes are contamination or bioinformatic artifacts.
merged_into
H-5 - Early A-B diversity reflects two or more separate zoonotic introductions, not one
source
S-1 - Pekar et al. 2022 — molecular epidemiology of multiple zoonotic origins of SARS-CoV-2
locator
Results, intermediate-haplotype analysis
quote
These findings cast doubt on the claim that transitional C/C or T/T haplotypes between lineages A and B circulated in humans

Load-bearing sub-claim: if the intermediates were real, a single introduction that mutated within humans is back on the table; if they are artifacts, the two-mutation gap must be bridged by two introductions.

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added after the FLF submission deadline

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