EpiStack

O-69 - BANAL RBDs match 15-16 of 17 hACE2-contact residues vs only 11-17 for RaTG13

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Properties8
type
observation
id
O-69
statement
Of the 17 RBD residues that contact human ACE2, 16/17 are conserved in BANAL-52/103 (one mismatch, H498Q) and 15/17 in BANAL-236 (K493Q, H498Q), versus only 13/17 for the Cambodian R. shameli virus and 11/17 for RaTG13 - the BANAL RBDs are far closer to SARS-CoV-2 at the receptor interface than RaTG13.
link_state
linked
source
S-52 - Temmam et al. 2022 Nature — BANAL Laos bat coronaviruses
locator
Results ('Bat Sarbecovirus evolutionary history'); Fig 1d
quote
16 are conserved between SARS-CoV-2 and BANAL-52 or BANAL-103 (one mismatch, H498Q), and 15/17 are conserved for BANAL-236 (two mismatches, K493Q and H498Q) whereas ... 11/17 for the Chinese bat R. affinis RaTG13 virus
data_basis

Of the 17 RBD residues that contact human ACE2, 16/17 are conserved in BANAL-52/103 (one mismatch, H498Q) and 15/17 in BANAL-236 (K493Q, H498Q), versus only 13/17 for the Cambodian R. shameli virus and 11/17 for RaTG13 - the BANAL RBDs are far closer to SARS-CoV-2 at the receptor interface than RaTG13.

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