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O-71 - A wild, unmodified BANAL-236 enters and replicates in human cells via hACE2

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Properties7
type
observation
id
O-71
statement
BANAL-236 spike-pseudotyped lentivirus enters hACE2-expressing HEK-293T cells (but not ACE2-negative controls) and is blocked by SARS-CoV-2-neutralizing sera, and live BANAL-236 virus replicates in human Calu-3 and Caco-2 cells expressing endogenous ACE2 - a wild bat virus infecting human cells without adaptation.
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linked
source
S-52 - Temmam et al. 2022 Nature — BANAL Laos bat coronaviruses
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Results ('Virus replication in human cells'); Fig 4
data_basis

BANAL-236 spike-pseudotyped lentivirus enters hACE2-expressing HEK-293T cells (but not ACE2-negative controls) and is blocked by SARS-CoV-2-neutralizing sera, and live BANAL-236 virus replicates in human Calu-3 and Caco-2 cells expressing endogenous ACE2 - a wild bat virus infecting human cells without adaptation.

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