O-71 - A wild, unmodified BANAL-236 enters and replicates in human cells via hACE2
BANAL-236 spike-pseudotyped lentivirus enters hACE2-expressing HEK-293T cells (but not ACE2-negative controls) and is blocked by SARS-CoV-2-neutralizing sera, and live BANAL-236 virus replicates in human Calu-3 and Caco-2 cells expressing endogenous ACE2 - a wild bat virus infecting human cells without adaptation.
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Why this is evidence
A wild, unmodified bat virus (BANAL-236) entering and replicating in human cells via hACE2 shows human-infectivity needs no laboratory work — favouring H-41/H-42 over H-43.