O-96 - Choline deficiency lowered serum cholesterol ~15% in deficient men only
O-96 — Consistent with choline/phosphatidylcholine’s role in hepatic VLDL assembly and lipid export; a mechanistic link between choline status and circulating lipids.
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Why this is evidence
A ~15% fall in serum cholesterol only in the deficient arm reflects impaired hepatic VLDL/lipid export when choline is withdrawn — a metabolic deficiency sign H-39 (essential) predicts; H-48 (not essential) predicts endogenous synthesis prevents any such derangement.