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EpiStack v1 — FLF competition
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analyses
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eggs
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evidence links
Folder: v1/analyses/eggs/evidence-links
132 items under this folder.
Jul 24, 2026
E-1 - O-7 x HC-13 — greater satiety under matched protein
Jul 24, 2026
E-103 - O-100 x HC-15 — non-differential error attenuates toward null
Jul 24, 2026
E-104 - O-101 x HC-15 — FFQ error quantified hence correctable
Jul 24, 2026
E-107 - O-32 x HC-5 — a lipid-independent (non-cholesterol) atherogenic pathway exists
Jul 24, 2026
E-111 - O-48 x HC-5 — direction of egg-CVD differs by region
Jul 24, 2026
E-117 - O-75 x HC-5 — egg cholesterol raises plasma cholesterol linearly, no threshold
Jul 24, 2026
E-12 - O-80 x HC-7 — responses normally distributed, ApoE4 only a trend
Jul 24, 2026
E-122 - O-48 × HC-2 — region interaction non-significant, heterogeneity persists within regions
Jul 24, 2026
E-126 - O-72 × HC-2 — second Asian cohort shows no egg-CVD inverse
Jul 24, 2026
E-127 - O-108 × HC-2 — within-Asia U-shape reframes region as dose-position
Jul 24, 2026
E-128 - O-8 × HC-2 — Asian inverse measured only below 1 egg per day
Jul 24, 2026
E-13 - O-81 x HC-7 — pooled n=395 ApoE null for dietary cholesterol
Jul 24, 2026
E-130 - O-42 × HC-2 — few US high consumers limit Western high-intake estimate
Jul 24, 2026
E-131 - O-17 × HC-2 — same region gradient significant for T2D
Jul 24, 2026
E-14 - O-98 x HC-7 — no differential response by absorber phenotype
Jul 24, 2026
E-20 - O-68 x HC-6 — no lipid change at 4 eggs-day for 4 weeks
Jul 24, 2026
E-38 - O-72 × HC-1 — KoGES whole-cohort egg-CVD null
Jul 24, 2026
E-58 - O-55 x HC-3 — Japan (JPHC) null both sexes
Jul 24, 2026
E-77 - O-45 x HC-4 — significant egg-T2D interaction on CVD, strata null
Jul 24, 2026
E-78 - O-49 x HC-4 — diabetic-subgroup meta egg-CVD RR 1.25-1.40
Jul 24, 2026
E-94 - O-48 x HC-10 — egg-CVD region gradient Asia inverse US-Europe null
Jul 24, 2026
E-96 - O-57 x HC-15 — small egg HRs need only modest confounding
Jul 23, 2026
E-116 - O-71 x HC-5 — biomarker-measured cohort association overturned by RCTs
Jul 23, 2026
E-132 - O-71 × HC-2 — protective cohort association RCT-refuted, healthy-user template
Jul 23, 2026
E-17 - O-28 x HC-6 — serum cholesterol rises with dietary cholesterol in feeding
Jul 23, 2026
E-52 - O-70 × HC-1 — cohort estimates imply implausible causal egg effect
Jul 23, 2026
E-97 - O-69 x HC-15 — near-universal food-mortality significance
Jul 23, 2026
E-98 - O-70 x HC-15 — implausible implied causal magnitudes
Jul 23, 2026
E-99 - O-71 x HC-15 — cohort-RCT beta-carotene discrepancy
Jul 23, 2026
E-10 - O-96 × HC-14 — serum cholesterol falls on choline-free diet
Jul 23, 2026
E-100 - O-91 x HC-15 — FFQ energy under-reported ~35 percent, instrument-driven
Jul 23, 2026
E-101 - O-92 x HC-15 — protein density escapes under-reporting bias
Jul 23, 2026
E-102 - O-93 x HC-15 — under-reporting is BMI-correlated (differential)
Jul 23, 2026
E-105 - O-1 x HC-5 — most subjects buffer added dietary cholesterol
Jul 23, 2026
E-106 - O-3 x HC-5 — plasma cholesterol tracks fat quality over cholesterol quantity
Jul 23, 2026
E-108 - O-41 x HC-5 — egg effect is a function of the comparator, not a fixed exposure
Jul 23, 2026
E-109 - O-43 x HC-5 — eggs co-occur with an unhealthy pattern (confounding structure)
Jul 23, 2026
E-11 - O-2 x HC-7 — rise tracks failed synthesis suppression
Jul 23, 2026
E-110 - O-44 x HC-5 — egg association vanishes on lifestyle (not cholesterol) adjustment
Jul 23, 2026
E-112 - O-58 x HC-5 — dietary cholesterol per se carries a monotonic dose-response
Jul 23, 2026
E-113 - O-60 x HC-5 — egg association vanishes on cholesterol adjustment
Jul 23, 2026
E-114 - O-62 x HC-5 — habitual egg dose leaves steady-state TMAO unmoved
Jul 23, 2026
E-115 - O-64 x HC-5 — egg-form choline is inert for TMAO
Jul 23, 2026
E-118 - O-81 x HC-5 — cholesterol response is genotype-invariant, unlike fat
Jul 23, 2026
E-119 - O-82 x HC-5 — genotype modulates the fat response but not cholesterol
Jul 23, 2026
E-120 - O-103 x HC-5 — egg choline feeds the TMAO pathway dose-dependently
Jul 23, 2026
E-121 - O-105 x HC-5 — egg-TMAO rise is transient, not a sustained exposure
Jul 23, 2026
E-123 - O-86 × HC-2 — PURE multi-region null consistent across regions
Jul 23, 2026
E-124 - O-87 × HC-2 — PURE MI signal not replicated in ONTARGET
Jul 23, 2026
E-125 - O-88 × HC-2 — PURE heterogeneity is NS subgroup not region
Jul 23, 2026
E-129 - O-84 × HC-2 — regional exposure-range variation, none above 1 egg per day
Jul 23, 2026
E-15 - O-4 x HC-6 — no HDL-C difference in 3-month egg RCT
Jul 23, 2026
E-16 - O-5 x HC-6 — null TC-LDL-TG in 3-month egg RCT
Jul 23, 2026
E-18 - O-50 x HC-6 — eggs lowered LDL-C less than high-carb breakfast
Jul 23, 2026
E-19 - O-51 x HC-6 — HDL-TG-nonHDL null between egg and high-carb
Jul 23, 2026
E-2 - O-25 × HC-12 — 77% of NE SE outbreaks traced to intact Grade A eggs
Jul 23, 2026
E-21 - O-75 x HC-6 — TC rose 1.47 mg-dL per 100 mg cholesterol, linear
Jul 23, 2026
E-22 - O-76 x HC-6 — LDL rose 1.38 mg-dL per 100 mg cholesterol
Jul 23, 2026
E-23 - O-77 x HC-6 — no HDL-TG dose response to dietary cholesterol
Jul 23, 2026
E-24 - O-78 x HC-6 — apoB rose ~10% across 0-4 egg diets
Jul 23, 2026
E-25 - O-80 x HC-6 — cholesterol responsiveness wide but mostly positive
Jul 23, 2026
E-26 - O-97 x HC-6 — 3 whole eggs-day raised HDL-C on carb-restricted diet
Jul 23, 2026
E-27 - O-98 x HC-6 — LDL-C and LDL-HDL ratio unchanged incl hyper-absorbers
Jul 23, 2026
E-28 - O-62 x HC-9 — 4 eggs-day no fasting TMAO rise (normal renal)
Jul 23, 2026
E-29 - O-63 x HC-9 — free choline raises fasting TMAO 6-fold
Jul 23, 2026
E-3 - O-26 × HC-12 — SE outbreaks egg-associated 44% vs 15% other serotypes
Jul 23, 2026
E-30 - O-64 x HC-9 — phosphatidylcholine (no matrix) also no TMAO rise
Jul 23, 2026
E-31 - O-9 × HC-1 — Kadoorie 11% lower total CVD
Jul 23, 2026
E-32 - O-10 × HC-1 — Kadoorie lower IHD and major coronary events
Jul 23, 2026
E-33 - O-11 × HC-1 — Kadoorie 26% lower haemorrhagic stroke
Jul 23, 2026
E-34 - O-12 × HC-1 — Kadoorie 10% lower ischaemic stroke
Jul 23, 2026
E-35 - O-13 × HC-1 — Kadoorie 18% lower CVD mortality
Jul 23, 2026
E-36 - O-44 × HC-1 — Harvard egg-CVD null after adjustment
Jul 23, 2026
E-37 - O-59 × HC-1 — +half egg-day higher CVD and mortality (US pooled)
Jul 23, 2026
E-39 - O-86 × HC-1 — PURE egg intake null for CVD and mortality
Jul 23, 2026
E-4 - O-27 × HC-12 — NE bulk raw eggs yield SE 10% vs 0%, tracks illness geography
Jul 23, 2026
E-40 - O-87 × HC-1 — PURE lower MI not replicated in ONTARGET
Jul 23, 2026
E-41 - O-89 × HC-1 — ONTARGET-TRANSCEND egg-CVD null
Jul 23, 2026
E-42 - O-108 × HC-1 — China-PAR U-shaped egg-CVD
Jul 23, 2026
E-43 - O-109 × HC-1 — China-PAR U-shaped egg-mortality
Jul 23, 2026
E-44 - O-65 x HC-9 — choline absorbed in egg arm despite TMAO null
Jul 23, 2026
E-45 - O-67 x HC-9 — egg white doesn't suppress choline-driven TMAO
Jul 23, 2026
E-46 - O-103 x HC-9 — egg ingestion raises TMAO dose-dependently
Jul 23, 2026
E-47 - O-104 x HC-9 — TMAO rises only at -=2 yolks, plateaus 4-6
Jul 23, 2026
E-48 - O-105 x HC-9 — egg TMAO rise is postprandial, not fasting
Jul 23, 2026
E-49 - O-47 × HC-1 — 33-cohort meta null point estimate with high heterogeneity
Jul 23, 2026
E-5 - O-20 x HC-11 — PETIT RCT confirmed-allergy 8% vs 38%
Jul 23, 2026
E-50 - O-48 × HC-1 — meta region gradient Asian inverse vs Western null
Jul 23, 2026
E-51 - O-58 × HC-1 — dietary-cholesterol dose-response harm, no threshold
Jul 23, 2026
E-53 - O-106 x HC-9 — all subjects convert egg choline to TMAO
Jul 23, 2026
E-54 - O-107 x HC-9 — no hsCRP-oxLDL change despite egg TMAO rise
Jul 23, 2026
E-55 - O-17 x HC-3 — region gradient US+-Europe-null-Asia-inverse
Jul 23, 2026
E-56 - O-31 x HC-3 — US 1.18 (I2 0%) vs non-US 0.97 split
Jul 23, 2026
E-57 - O-29 x HC-3 — Swedish men null, register outcomes
Jul 23, 2026
E-59 - O-32 x HC-8 — dietary TMAO supplementation raises plaque in mice
Jul 23, 2026
E-6 - O-94 × HC-14 — plasma choline depletes on choline-free diet
Jul 23, 2026
E-60 - O-18 x HC-3 — association concentrates at low diet quality
Jul 23, 2026
E-61 - O-43 x HC-3 — eggs co-occur with unhealthy Western pattern
Jul 23, 2026
E-62 - O-19 x HC-3 — substitution helps only vs prudent foods
Jul 23, 2026
E-63 - O-15 x HC-3 — US signal null in men, positive in women
Jul 23, 2026
E-64 - O-43 × HC-1 — higher egg eaters carry more CVD risk factors (confounding structure)
Jul 23, 2026
E-65 - O-85 × HC-1 — no adverse lipid shift undercuts the cholesterol-mediated harm mechanism
Jul 23, 2026
E-66 - O-88 × HC-1 — isolated non-replicated protective subgroup signal fits noise around null
Jul 23, 2026
E-67 - O-33 x HC-8 — TMAO drives macrophage foam-cell formation
Jul 23, 2026
E-68 - O-35 x HC-8 — suppressing gut-flora TMAO abolishes atherosclerosis
Jul 23, 2026
E-69 - O-36 x HC-8 — FMO3 (TMAO-generating enzyme) segregates with lesion area
Jul 23, 2026
E-7 - O-21 x HC-11 — PETIT acute-reaction-admission pattern bounds dropout artefact
Jul 23, 2026
E-70 - O-37 x HC-8 — TMAO predicts 3-year incident events in humans
Jul 23, 2026
E-71 - O-38 x HC-8 — TMAO dose-dependent with prevalent CVD, adjusted
Jul 23, 2026
E-72 - O-63 x HC-8 — raising TMAO ~6-fold raised platelet reactivity in humans
Jul 23, 2026
E-73 - O-66 x HC-8 — platelet reactivity correlates with TMAO in humans
Jul 23, 2026
E-74 - O-4 x HC-4 — no HDL-C difference in 3-month egg RCT (prediabetes-T2D)
Jul 23, 2026
E-75 - O-5 x HC-4 — null TC-LDL-TG in 3-month egg RCT (prediabetes-T2D)
Jul 23, 2026
E-76 - O-6 x HC-4 — no glycemic-control difference in 3-month egg RCT
Jul 23, 2026
E-79 - O-50 x HC-4 — eggs less LDL-lowering than high-carb breakfast
Jul 23, 2026
E-8 - O-1 x HC-7 — 69-31 compensation split
Jul 23, 2026
E-80 - O-51 x HC-4 — non-HDL, HDL, TG, CRP null egg vs high-carb
Jul 23, 2026
E-81 - O-52 x HC-4 — HOMA-IR favored eggs over high-carb breakfast
Jul 23, 2026
E-82 - O-54 x HC-4 — systolic BP fell more on egg breakfast
Jul 23, 2026
E-83 - O-73 x HC-4 — egg-CVD HR 2.81 in diabetics only (KoGES)
Jul 23, 2026
E-84 - O-74 x HC-4 — egg intake not associated with fasting lipids (KoGES)
Jul 23, 2026
E-85 - O-97 x HC-4 — 3 eggs-day raised HDL-C in metabolic-syndrome men
Jul 23, 2026
E-86 - O-98 x HC-4 — LDL-C and LDL-HDL ratio unchanged incl hyper-absorbers
Jul 23, 2026
E-87 - O-19 x HC-10 — egg-removal effect comparator-dependent (T2D)
Jul 23, 2026
E-88 - O-39 x HC-10 — removing eggs vs healthy proteins lowers CVD
Jul 23, 2026
E-89 - O-40 x HC-10 — removing eggs vs healthy proteins lowers mortality
Jul 23, 2026
E-9 - O-95 × HC-14 — ALT rise (liver dysfunction) on choline-free diet
Jul 23, 2026
E-90 - O-41 x HC-10 — egg-removal depends on comparator, eggs rank near processed meat
Jul 23, 2026
E-91 - O-46 x HC-10 — Harvard substitution eggs neutral vs healthy better than red-processed meat
Jul 23, 2026
E-92 - O-17 x HC-10 — egg-T2D region gradient US-Europe-Asia
Jul 23, 2026
E-93 - O-31 x HC-10 — egg-T2D US vs non-US split
Jul 23, 2026
E-95 - O-18 x HC-10 — egg-T2D interaction with background diet quality
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interactive Bayesian view — separate from the graph above
added after the FLF submission deadline