O-95 - Choline deficiency raised serum ALT (0.42 to 0.62 mukat-L) in deficient men only, other liver-renal tests unchanged
O-95 — Elevated aminotransferase indicates hepatocellular stress; the isolated ALT rise (with other tests normal) marks incipient, reversible liver dysfunction attributable specifically to choline removal.
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Why this is evidence
A reversible ALT rise — a sign of incipient liver dysfunction — appearing only in the choline-deficient arm is the organ-dysfunction deficiency sign H-39 (essential) predicts a choline-free diet produces; H-48 (not essential: synthesis suffices, no reliable deficiency) predicts no such dysfunction.