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O-95 - Choline deficiency raised serum ALT (0.42 to 0.62 mukat-L) in deficient men only, other liver-renal tests unchanged

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Properties8
type
observation
id
O-95
statement
During the 3-week choline-deficient period, serum alanine aminotransferase (ALT) rose steadily from a mean 0.42 to 0.62 mukat/L in the deficient group only (a sign of incipient liver dysfunction), while other liver and renal function tests were unchanged and the control group showed no change; the biochemical signs reversed on repletion.
link_state
linked
source
S-7 - Zeisel 1991 - Choline, an essential nutrient for humans
locator
Abstract; Results
data_basis
quote
serum alanine aminotransferase activity increased steadily from a mean of 0.42 mukat/liter to a mean of 0.62 mukat/liter

O-95 — Elevated aminotransferase indicates hepatocellular stress; the isolated ALT rise (with other tests normal) marks incipient, reversible liver dysfunction attributable specifically to choline removal.

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