O-29 - Cohort of Swedish Men - egg intake and T2D functionally null (p-trend 0.06) with register-based outcomes
O-29 — Adjusted for age, BMI, physical activity, education, smoking, energy, alcohol, coffee, red/processed meat, fish, fruit, vegetables, white bread, fibre and CVD history; T2D captured via linked national registers, reducing outcome misclassification. See
Link to originalMethodology
Cohort of Swedish Men (COSM): 39,610 men aged 45-79, single baseline FFQ egg exposure, followed 1998-2012 (15y) for incident T2D captured via linked national registers (4,173 cases). Cox models adjusted for age, BMI, physical activity, education, smoking, total energy, alcohol, coffee, red/processed meat, fish, fruit, vegetables, white bread, fibre and CVD history; a further model added dietary cholesterol and protein. The paper also updates a dose-response meta-analysis to 12 prospective cohorts (287,963 participants, 16,264 cases), stratified into US vs non-US studies and tested for non-linearity.
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Why this is evidence
A functionally-null European cohort with register-based (low-misclassification) outcomes is predicted by H-8 (Europe null) and H-9 (non-US null); it is evidence against H-51’s uniform non-null effect. The register-based ascertainment weakens the measurement-error escape a uniform-effect defender could otherwise invoke.