O-44 - Moderate egg intake not associated with CVD in Harvard cohorts (adjusted HR 0.93), crude 1.10 reversing to null on adjustment
The headline Western null. The estimate moved from a modestly positive crude HR (1.10) to null/inverse (0.93) as lifestyle and co-consumed-food covariates were added. The null was robust to modeling diet as baseline-only (0.98, 0.90-1.07), simple update (1.00, 0.90-1.10), or cumulative average, and to using total egg intake including eggs in baked goods (0.98, 0.93-1.03).
Link to original
Why this is evidence
The egg-CVD association reverses to null on adjustment for correlated lifestyle and co-consumed foods — not for dietary cholesterol — pointing to confounding (H-54). Contrast O-60, where the removal comes specifically from cholesterol adjustment (H-26): the two attenuations implicate different operative accounts.