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O-44 - Moderate egg intake not associated with CVD in Harvard cohorts (adjusted HR 0.93), crude 1.10 reversing to null on adjustment

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Properties7
type
observation
id
O-44
statement
In the pooled Harvard cohorts (NHS, NHS II, HPFS; 5,540,314 person-years; 14,806 incident CVD events), the age-adjusted HR for >=1 egg/day vs <1 egg/month was a non-significant 1.10 (0.97-1.23); after full multivariable adjustment for correlated lifestyle and diet (model 3) it was 0.93 (0.82-1.05), with per-1-egg/day HR 0.98 (0.92-1.04), coronary heart disease 0.90 (0.77-1.05), stroke 0.99 (0.81-1.22), and >=2 eggs/day 0.91 (0.72-1.15).
link_state
linked
source
S-19 - Drouin-Chartier 2020 BMJ - egg consumption and CVD in NHS, NHSII, HPFS
locator
Results, Table 1
quote
the association seemed to be reversed, but remained non-significant (pooled hazard ratio 0.93, 95% confidence interval 0.82 to 1.05)

The headline Western null. The estimate moved from a modestly positive crude HR (1.10) to null/inverse (0.93) as lifestyle and co-consumed-food covariates were added. The null was robust to modeling diet as baseline-only (0.98, 0.90-1.07), simple update (1.00, 0.90-1.10), or cumulative average, and to using total egg intake including eggs in baked goods (0.98, 0.93-1.03).

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