O-50 - Eggs lowered LDL-C less than an energy-matched high-carb breakfast in metabolic-syndrome-prediabetes adults
The paper’s adverse-leaning signal for eggs: LDL-C still decreased in absolute terms on the egg condition, but decreased more on the non-egg (high-sugar/high-carb) comparator. Baseline LDL-C 119 mg/dL. Own-experiment crossover (each subject their own control).
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Randomized two-period crossover with >=4-week washout. 145 screened, 39 randomized, 30 completed both conditions (19 F / 11 M; mean age 54.1 y, BMI 31.9; 63% with >=3 metabolic-syndrome components). Each condition run 4 weeks. Egg condition: 2 whole eggs/day, 6 days/week (12 eggs/week) within a ~554 kcal breakfast (25.8% protein, 41.4% CHO). Non-egg condition: energy-matched (~555 kcal) higher-carbohydrate/higher-sugar breakfast (12.1% protein, 60.4% CHO; +25 g sugar vs egg). Breakfast ~25% of daily energy. No formal multiple-testing correction (authors note type-I-error risk).
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Why this is evidence
Eggs were less LDL-favourable than the energy-matched high-carb comparator — the adverse-lipid direction H-33 predicts (egg cholesterol more atherogenic in this at-risk group) and counter to H-4’s lipid-safety claim. H-19 (glycemic) is silent on LDL.