O-60 - Egg-CVD and egg-mortality associations become non-significant after adjusting for dietary cholesterol (6 US cohorts)
The key attenuation result: once dietary cholesterol is in the model, the egg association vanishes — distinct from the raw egg association (the same data, different adjustment set).
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Why this is evidence
The egg association becoming non-significant once dietary cholesterol is in the model is the signature of cholesterol as the mediator (H-26). A non-cholesterol egg component or pure dietary-pattern confounding (H-54) would not be removed specifically by cholesterol adjustment; H-3 makes cholesterol a minor lever, so full attenuation to it is less expected.