O-87 - Higher egg intake associated with lower myocardial infarction risk in PURE but not replicated in ONTARGET TRANSCEND
MI category HRs (CVD-free): 1-<3/wk 0.83, 3-<5/wk 0.78, 5-<7/wk 0.79, >=7/wk 0.84. The paper explicitly cautions this is one of many outcomes examined and not observed in the other two cohorts.
Link to original
Why this is evidence
The single protective clinical signal (MI in PURE) fails to replicate in ONTARGET/TRANSCEND and is flagged by the authors as a likely multiple-testing artefact. A genuine population effect (H-22) should replicate across cohorts; H-7 (confounded) and H-50 (chance/artefact) predict exactly this non-replication of an isolated protective signal.