O-85 - Higher egg intake not associated with adverse blood lipids and associated with slightly lower blood pressure in PURE
Adjusted means across egg categories are essentially flat for every lipid fraction. The only lipid-related signals are directionally favourable (lower BP), i.e. no adverse metabolic effect of higher egg intake in this cohort.
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Why this is evidence
H-27 frames egg harm as operating through egg cholesterol raising atherogenic lipids; flat LDL/total-cholesterol/ApoB across egg categories (plus slightly lower blood pressure) means that necessary first link is not engaged, lowering P(harm) under H-27 and making the clinical null mechanistically coherent under H-21. H-6 (protection) is mildly consistent with the lower blood pressure. It discriminates the cholesterol-mediated harm member from the null/protective members via the absent intermediate.