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H-15 - Gut flora convert dietary phosphatidylcholine-choline to TMAO, which causally promotes atherosclerosis independent of lipids

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Properties8
type
hypothesis
id
H-15
state
active
question
Is there a gut-flora-dependent choline->TMAO pathway by which dietary phosphatidylcholine/choline promotes atherosclerosis?
statement
Dietary phosphatidylcholine/choline is metabolized by gut flora to TMAO, which causally promotes atherosclerosis by upregulating macrophage scavenger receptors and foam-cell formation — a lipid-independent, microbiota-dependent atherogenic pathway.
cluster
HC-8 - Causal status of elevated TMAO for human atherosclerosis
source
S-28 - Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease (Wang et al. 2011, Nature)
locator
Abstract; Discussion

The paper’s central mechanistic hypothesis, strongly supported in mice. Relevant to eggs because egg yolk is a major dietary source of phosphatidylcholine/choline.

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