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EpiStack v1 — FLF competition
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analyses
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eggs
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hypotheses
Folder: v1/analyses/eggs/hypotheses
55 items under this folder.
Jul 23, 2026
merged
Jul 23, 2026
H-1 - Plasma-cholesterol response to dietary cholesterol is highly individualized (hypo- vs hyper-responders)
Jul 23, 2026
H-10 - Early stepwise egg introduction causally prevents egg allergy in high-risk infants
Jul 23, 2026
H-11 - Trans-ovarian (internal, pre-shell) contamination, not shell contamination, drives the SE egg epidemic
Jul 23, 2026
H-12 - Intact Grade A shell eggs are a major vehicle of the US Salmonella enteritidis epidemic
Jul 23, 2026
H-15 - Gut flora convert dietary phosphatidylcholine-choline to TMAO, which causally promotes atherosclerosis independent of lipids
Jul 23, 2026
H-16 - Elevated plasma TMAO is a clinically meaningful (causal) cardiovascular risk factor in humans
Jul 23, 2026
H-17 - Eggs are a relatively unhealthy protein source; benefit comes from replacing eggs with plant or fish protein
Jul 23, 2026
H-18 - The egg-health effect is a property of the comparator not of eggs alone, so eggs good-or-bad is ill-posed
Jul 23, 2026
H-19 - Substituting eggs for high-carb breakfast foods improves or does not worsen glycemic-insulin outcomes in adults at risk for T2D
Jul 23, 2026
H-2 - Feedback down-regulation of absorption and synthesis buffers dietary cholesterol in most people
Jul 23, 2026
H-20 - In dysglycemic adults, replacing high-carb breakfast foods with eggs modestly worsens LDL-C
Jul 23, 2026
H-21 - Moderate egg intake has no causal effect on CVD risk overall
Jul 23, 2026
H-22 - Region-population modifies the egg-CVD association (inverse in Asia, null in West)
Jul 23, 2026
H-23 - Egg's CVD impact is relative to the food it replaces (neutral vs healthy proteins, better than red-processed meat)
Jul 23, 2026
H-24 - Egg consumption raises CVD risk specifically in people with type 2 diabetes
Jul 23, 2026
H-26 - Dietary cholesterol content, not egg per se, is the operative exposure behind the egg-CVD association
Jul 23, 2026
H-27 - Higher dietary cholesterol - egg intake causally raises CVD and mortality risk (dose-response)
Jul 23, 2026
H-28 - The form-food-matrix of choline, not total choline content, determines TMAO generation
Jul 23, 2026
H-29 - Habitual whole-egg consumption does not meaningfully raise TMAO in people with normal renal function
Jul 23, 2026
H-3 - Dietary fat quality is a larger determinant of plasma cholesterol than dietary cholesterol quantity
Jul 23, 2026
H-30 - Impaired renal function may modify the TMAO response to egg-choline intake
Jul 23, 2026
H-31 - Nutritional-cohort diet-disease associations reflect cumulative bias and cannot support causal dietary claims
Jul 23, 2026
H-33 - Impaired insulin sensitivity in T2DM deranges cholesterol transport, making egg-derived dietary cholesterol more atherogenic in diabetics
Jul 23, 2026
H-34 - Egg-derived dietary cholesterol raises fasting LDL-total cholesterol linearly, roughly +1.4-1.5 mg-dL per 100 mg
Jul 23, 2026
H-35 - Cholesterol responsiveness to dietary cholesterol is a continuous (normally distributed) trait, not a discrete responder-non-responder split
Jul 23, 2026
H-36 - APOE genotype by itself does not identify dietary-cholesterol hyper-responders
Jul 23, 2026
H-38 - The health effect of eggs depends on background diet, being least harmful when displacing refined carbohydrate
Jul 23, 2026
H-39 - Choline is an essential nutrient for humans when dietary methionine and folate are not in excess
Jul 23, 2026
H-4 - High egg intake does not harm blood lipids or glycemic control in people with prediabetes-T2D
Jul 23, 2026
H-40 - Whole eggs on a carbohydrate-restricted diet produce a net-favorable-neutral lipid response (HDL up, LDL-HDL preserved) even in hyper-absorbers
Jul 23, 2026
H-41 - The standard critiques of nutritional-cohort epidemiology are manageable, so well-conducted cohorts can support policy-relevant causal dietary inference
Jul 23, 2026
H-42 - Eating eggs (-=2 yolks) raises TMAO production, feeding egg choline into the TMAO pathway
Jul 23, 2026
H-43 - The egg-induced TMAO rise may be clinically benign because it is postprandial and unaccompanied by inflammatory-oxidative changes
Jul 23, 2026
H-44 - An intermediate egg intake of about 3 to 6 per week minimizes CVD and mortality risk with harm at both lower and higher intake
Jul 23, 2026
H-45 - TMAO is a non-causal marker not itself atherogenic in humans
Jul 23, 2026
H-46 - Early egg introduction does not causally prevent allergy
Jul 23, 2026
H-47 - Egg satiety is fully explained by protein content
Jul 23, 2026
H-48 - Dietary choline is not an essential nutrient
Jul 23, 2026
H-49 - Some other overall egg-CVD relationship
Jul 23, 2026
H-5 - Eggs increase satiety and reduce hunger beyond their protein content
Jul 23, 2026
H-50 - Some other origin of regional heterogeneity
Jul 23, 2026
H-51 - Some other egg-T2D structure
Jul 23, 2026
H-52 - Some other net egg effect in diabetics
Jul 23, 2026
H-53 - Some other egg lipid-profile effect
Jul 23, 2026
H-54 - Some other operative exposure
Jul 23, 2026
H-55 - Some other responder structure
Jul 23, 2026
H-56 - Some other egg-TMAO relationship
Jul 23, 2026
H-57 - Some other egg-health characterization
Jul 23, 2026
H-58 - Some other egg-Salmonella account
Jul 23, 2026
H-59 - Some intermediate epistemic standing
Jul 23, 2026
H-6 - Moderate egg consumption causally lowers CVD risk in Chinese adults
Jul 23, 2026
H-7 - Inverse egg-CVD association in China Kadoorie reflects healthy-user confounding not causation
Jul 23, 2026
H-8 - Egg-T2D association is region-population-dependent - positive in US, null in Europe, null-to-inverse in Asia
Jul 23, 2026
H-9 - US egg-T2D association reflects residual confounding by the co-consumed Western dietary pattern, not a causal egg effect
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