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H-26 - Dietary cholesterol content, not egg per se, is the operative exposure behind the egg-CVD association

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Properties8
type
hypothesis
id
H-26
state
active
question
Is the egg-CVD association driven by egg's dietary cholesterol content rather than eggs themselves?
statement
The dietary cholesterol content of eggs, not eggs per se, is the operative exposure driving the observed egg-CVD and egg-mortality associations; eggs matter for cardiovascular risk only via the cholesterol they contribute.
cluster
HC-5 - Operative exposure behind the egg-cardiovascular association
source
S-21 - Zhong 2019 JAMA - dietary cholesterol-egg consumption and incident CVD and mortality, 6 pooled US cohorts
locator
Results; Discussion; Conclusions

The paper’s proposed mechanism, motivated by the egg association vanishing once dietary cholesterol is adjusted for while dietary cholesterol retains a monotonic dose-response.

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