EpiStack

H-33 - Impaired insulin sensitivity in T2DM deranges cholesterol transport, making egg-derived dietary cholesterol more atherogenic in diabetics

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Properties8
type
hypothesis
id
H-33
state
active
question
What mechanism could make eggs more cardiovascularly harmful in people with diabetes?
statement
The diabetic-specific egg harm arises because low insulin sensitivity in T2DM raises total/VLDL/LDL cholesterol and alters cholesterol transport (decreased apolipoprotein E, increased apolipoprotein C3), so the extra dietary cholesterol delivered by eggs is handled abnormally and is more atherogenic in diabetics than in non-diabetics.
cluster
HC-4 - Cardiometabolic effect of eggs in people with diabetes, prediabetes, or metabolic syndrome
source
S-14 - Jang 2018 Nutrition and Diabetes - egg consumption and CVD risk interacting with T2DM status, KoGES Ansung-Ansan
locator
Discussion

H-33 — Authors’ proposed biological mechanism for the interaction; speculative and not directly tested (no egg-stratified lipid or lipoprotein-subclass data in diabetics).

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