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H-38 - The health effect of eggs depends on background diet, being least harmful when displacing refined carbohydrate

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Properties8
type
hypothesis
id
H-38
state
active
question
Does the health effect of egg intake depend on the background diet or population?
statement
The cardiovascular effect of eggs is contingent on the background diet: eggs are least likely to be harmful (and possibly beneficial) when they displace refined carbohydrate in high-carbohydrate, lower-quality diets (e.g. China, South Asia, Africa, low-income populations), which could reconcile protective Asian and null/harmful Western findings.
cluster
HC-10 - Intrinsic versus comparator-background-diet contingency of egg-health (is the verdict well-posed)
source
S-91 - PURE study- egg intake, blood lipids, CVD and mortality in 50 countries (Dehghan 2020)
locator
Discussion

Advanced by the authors to explain why the US pooled cohort found harm while Kadoorie found protection and PURE found neutrality; also echoes the EAT-Lancet note that higher egg intake may benefit low-income populations with poor dietary quality.

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added after the FLF submission deadline

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