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H-29 - Habitual whole-egg consumption does not meaningfully raise TMAO in people with normal renal function

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Properties8
type
hypothesis
id
H-29
state
active
question
Does egg consumption raise TMAO (a proposed cardiovascular-harm pathway)?
statement
Habitual whole-egg consumption (up to ~4 eggs/day) does not meaningfully raise fasting TMAO - a proposed cardiovascular-harm mediator - in people with normal renal function, undercutting a TMAO-mediated harm pathway for eggs specifically.
cluster
HC-9 - Whether habitual egg intake produces a harm-relevant TMAO elevation
source
S-60 - Dietary choline supplements, but not eggs, raise fasting TMAO levels in participants with normal renal function- a randomized clinical trial (Wilcox et al. 2021, Am J Med)
locator
Discussion, egg-specific conclusion

A candidate answer to the harm-mechanism sub-question, notable for coming from the lab (Hazen/Tang) that built the TMAO-harm hypothesis.

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