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H-30 - Impaired renal function may modify the TMAO response to egg-choline intake

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Properties8
type
hypothesis
id
H-30
state
active
question
Does renal function modify the TMAO response to egg/choline intake (for whom)?
statement
In people with impaired renal function, egg or choline intake may raise TMAO (unlike in those with normal renal function), because TMAO is cleared almost exclusively by the kidney and could accumulate when clearance is reduced.
cluster
HC-9 - Whether habitual egg intake produces a harm-relevant TMAO elevation
source
S-60 - Dietary choline supplements, but not eggs, raise fasting TMAO levels in participants with normal renal function- a randomized clinical trial (Wilcox et al. 2021, Am J Med)
locator
Discussion/Limitations, renal-clearance caveat

A for-whom candidate answer flagged by the authors as a limitation; the trial deliberately restricted to normal renal function, so this remains untested here.

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