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H-36 - APOE genotype by itself does not identify dietary-cholesterol hyper-responders

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Properties8
type
hypothesis
id
H-36
state
active
question
Does APOE genotype (E4) identify who hyper-responds to dietary cholesterol (for whom)?
statement
APOE genotype (in particular E4 carriage) does not by itself identify who hyper-responds to dietary cholesterol; the popular 'ApoE4 carriers hyper-respond to dietary cholesterol' claim does not hold for the dietary-cholesterol challenge specifically.
cluster
HC-7 - Nature of inter-individual variation in cholesterol response to dietary cholesterol
source
S-62 - Weggemans, Zock, Ordovas, Pedro-Botet and Katan 2001 Atherosclerosis - ApoE genotype and response of serum cholesterol to dietary fat, cholesterol and cafestol
locator
Discussion/Abstract, conclusion on practical utility

A for-whom candidate answer. Remains contested in the wider literature (other studies disagree); here it is supported by the largest pooled-genotype dataset but the dietary-cholesterol null is only moderately powered.

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