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H-42 - Eating eggs (-=2 yolks) raises TMAO production, feeding egg choline into the TMAO pathway

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Properties8
type
hypothesis
id
H-42
state
active
question
Does egg consumption raise TMAO exposure?
statement
Habitual egg consumption, at least at >=2 yolks per meal, raises trimethylamine-N-oxide production, so egg-derived choline measurably enters the purported atherogenic TMAO pathway.
cluster
HC-9 - Whether habitual egg intake produces a harm-relevant TMAO elevation
source
S-47 - Effect of egg ingestion on trimethylamine-N-oxide production in humans- a randomized, controlled, dose-response study (Miller et al. 2014, AJCN)
locator
Abstract; Conclusions

Well-supported for postprandial flux; its extrapolation to chronic exposure under normal (non-low-choline) diets and to hard outcomes is what remains uncertain.

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