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H-35 - Cholesterol responsiveness to dietary cholesterol is a continuous (normally distributed) trait, not a discrete responder-non-responder split

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Properties8
type
hypothesis
id
H-35
state
active
question
Is dietary-cholesterol responsiveness a discrete responder trait or a continuous distribution?
statement
Individual sensitivity of plasma cholesterol to dietary cholesterol is a continuously (approximately normally) distributed quantitative trait rather than a discrete hypo- vs hyper-responder dichotomy.
cluster
HC-7 - Nature of inter-individual variation in cholesterol response to dietary cholesterol
source
S-42 - Ginsberg 1994 Arterioscler Thromb — dose-response of dietary cholesterol-egg feeding on lipoproteins in healthy young men
locator
Results; Discussion (individual variability)

Reading of the observed normal spread of responses. Uncertain: n=20 has limited power to distinguish a unimodal from a subtly bimodal distribution, and the ApoE4 trend hints at genetic structure underneath the spread.

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added after the FLF submission deadline

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