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H-28 - The form-food-matrix of choline, not total choline content, determines TMAO generation

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Properties8
type
hypothesis
id
H-28
state
active
question
What determines the TMAO response to dietary choline - total choline amount or its chemical form/food matrix?
statement
The chemical form of dietary choline (free choline vs choline bound as phosphatidylcholine, including egg-yolk choline), not the total amount of choline ingested, determines gut-microbial TMA production and systemic TMAO; phosphatidylcholine is less bioavailable for TMA generation than free choline.
cluster
HC-9 - Whether habitual egg intake produces a harm-relevant TMAO elevation
source
S-60 - Dietary choline supplements, but not eggs, raise fasting TMAO levels in participants with normal renal function- a randomized clinical trial (Wilcox et al. 2021, Am J Med)
locator
Discussion, choline-form/bioavailability interpretation

The authors’ central mechanistic claim, discriminating between two rival TMAO models. Uncertain (the microbiome step is inferred, not directly measured here).

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