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H-34 - Egg-derived dietary cholesterol raises fasting LDL-total cholesterol linearly, roughly +1.4-1.5 mg-dL per 100 mg

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Properties8
type
hypothesis
id
H-34
state
active
question
Does egg-derived dietary cholesterol raise LDL/total cholesterol, and by how much per unit intake?
statement
Dietary cholesterol from eggs raises fasting total and LDL cholesterol in a linear, dose-dependent way — on the order of +1.4 to 1.5 mg/dL per 100 mg cholesterol — with the rise borne by LDL (and apoB particle number) rather than HDL, at least in healthy young men.
cluster
HC-6 - Effect of egg-egg-cholesterol intake on the atherogenic blood-lipid profile
source
S-42 - Ginsberg 1994 Arterioscler Thromb — dose-response of dietary cholesterol-egg feeding on lipoproteins in healthy young men
locator
Abstract; Conclusions

The quantified average causal effect from controlled feeding. Modest per 100 mg but monotonic; magnitude in other populations (older, hyper-responders, different background fat) is left open.

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