EpiStack

❯

❯

❯

❯

❯

O-104 - TMAO rose significantly only at -=2 yolks and urinary TMAO plateaued between 4 and 6 yolks

Jul 23, 20261 min read

Properties7

type: observation
id: O-104
statement: The TMAO rise was significant only from 2 yolks upward (1 yolk did not differ from 0; 2 yolks exceeded 0 at P<0.05), and urinary TMAO plateaued at the top of the range (4 and 6 yolks did not differ from each other but both exceeded 0/1/2 yolks), indicating a saturating dose-response.
link_state: linked
source: S-47 - Effect of egg ingestion on trimethylamine-N-oxide production in humans- a randomized, controlled, dose-response study (Miller et al. 2014, AJCN)
locator: Results (dose-response); Conclusions
quote: The consumption of >=2 eggs results in an increased formation of TMAO.

Threshold near 2 yolks and saturation beyond ~4 yolks: 236 → 433 → 634 → 944 → 900 umol/24h urinary TMAO.

added after the FLF submission deadline

A-39 - The -=2-yolk threshold and 4-6 yolk plateau imply saturating conversion capacity, bounding TMAO exposure from high egg intake
E-47 - O-104 x HC-9 — TMAO rises only at -=2 yolks, plateaus 4-6
S-47 - Effect of egg ingestion on trimethylamine-N-oxide production in humans- a randomized, controlled, dose-response study (Miller et al. 2014, AJCN)