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O-106 - Marked inter-individual variation in egg-to-TMAO conversion (-=4-fold), all subjects converted, men more than women

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Properties7
type
observation
id
O-106
statement
There was marked inter-individual variation in TMAO production from eggs (at least a 4-fold difference between subjects); all 6 subjects converted choline to TMAO (no non-converters), and men produced more TMAO than women at equivalent doses.
link_state
linked
source
S-47 - Effect of egg ingestion on trimethylamine-N-oxide production in humans- a randomized, controlled, dose-response study (Miller et al. 2014, AJCN)
locator
Results (individual variation)
quote
There was considerable variation between individuals in the TMAO response.

The 4-fold spread on n=6 flags a large host/microbiome effect on TMAO generation, though no discrete non-converter phenotype appeared.

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